Children & HNPP

Although people are believed not to have significant symptoms during childhood, below you will find literature on children and HNPP (new to old publications).

Many children will consider certain symptoms as normal, so these symptoms often go unnoticed. If HNPP runs in your family, you might be vigilant for this type of symptoms. For example: numbness in hand when writing or colouring or repetitive use, pains that are considered as growing pains, ankle sprains ...

Other symptoms described in literature and online in children: foot drop, delay in learning to walk (list in progress).

If you know there is a chance that your child has HNPP (50 % chance if you or your partner have it), you can make small changes to their lives without interrupting a normal childhood experience. Consult with a neurologist or medical professional when you suspect that your child has HNPP. Don't automatically assume that the symptoms are part of HNPP.  It might be something else that does have a cure or that needs medical attention.

Scientific literature on children and HNPP:

Monomelic Multifocal Neuropathy: An Unrecognized Electrophysiological Feature of Hereditary Neuropathy with Liability to Pressure Palsies in Childhood

04/2023

https://neurologyindia.com/article.asp?issn=0028-3886;year=2023;volume=71;issue=2;spage=329;epage=330;aulast=Lee
(A previously healthy 10-year-old girl visited our hospital with a 3-day history of weakness and sensory disturbances in the left hand. Muscle weakness was most prominent in the left ring and little fingers, and tingling sensation existed primarily in the left thumb, index, and middle fingers. These symptoms occurred after playing Korean Jacks called Gonggi for long hours with her left elbow on the table, propping her chin in the palm of her left hand.  )

Hereditary neuropathy with liability to pressure palsies (HNPP):

Intrafamilial phenotypic variability and early childhood refusal to walk as the presenting symptom

06/2022

https://pubmed.ncbi.nlm.nih.gov/35658923/
(A 4.5 years-old boy presented for in-patient evaluation due to refusal to walk.)

Although rare, border forms between CIDP and CMT also exist in children

03/2021

https://www.institut-myologie.org/en/2021/03/15/although-rare-border-forms-between-cidp-and-cmt-also-exist-in-children/

Hereditary Neuropathy with Liability to Pressure Palsies: A Rare Condition That Presents with Common Symptoms: A Case Report. 

11/2018

https://pubmed.ncbi.nlm.nih.gov/30489379/
(Case: A 13-year-old girl presented with paresthesia of the fourth and fifth fingers and the dorsal ulnar surface of the left hand.)

Hereditary neuropathy with liability to pressure palsies in childhood: Case series and literature update
05/2016 (only accessible if you pay)

https://pubmed.ncbi.nlm.nih.gov/27137093/

The LITAF/SIMPLE I92V sequence variant results in an earlier age of onset of CMT1A/HNPP diseases

1/2015

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284369/

Hereditary neuropathy with liability to pressure palsy presenting with hand drop in a young child.

09/2012

https://pubmed.ncbi.nlm.nih.gov/22953141/

Early-onset hereditary neuropathy with liability to pressure palsy

07/2007

https://pubmed.ncbi.nlm.nih.gov/17607607/

Hereditary neuropathy with liability to pressure palsies in childhood: report of a case and a brief review

03/2005

https://pubmed.ncbi.nlm.nih.gov/15668057/

Carpal tunnel syndrome in children
10/2003

https://pubmed.ncbi.nlm.nih.gov/14648946/ 

Hereditary neuropathy with liability to pressure palsies in infancy
07/2003

https://pubmed.ncbi.nlm.nih.gov/12849887/

Hereditary neuropathy with liability to pressure palsies in a toddler

12/2002

https://pubmed.ncbi.nlm.nih.gov/12499508/

https://n.neurology.org/content/59/12/2008.1.full

Hereditary neuropathy with liability to pressure palsies in childhood

08/2000

https://pubmed.ncbi.nlm.nih.gov/10948581/

Neuropatía hereditaria con susceptibilidad a la presión en la infancia
01/07/2000

https://www.neurologia.com/articulo/2000012

Hereditary neuropathy with liability to pressure palsies in children
12/1999

https://pubmed.ncbi.nlm.nih.gov/10593673/

Carpal tunnel syndrome in childhood: study of 6 cases

09/1998

https://pubmed.ncbi.nlm.nih.gov/9751292/ 

Pediatric bilateral carpal tunnel syndrome as first manifestation of hereditary neuropathy with liability to pressure palsies (HNPP)

05/1998

https://pubmed.ncbi.nlm.nih.gov/10210852/

https://www.kinderneurologie.eu/download/HNPP.pdf