Hereditary neuropathy with liability to pressure palsies (HNPP) is a genetic disorder of the peripheral nervous system, causing the nerves to be increasingly sensitive to pressure, injury or repetitive use. It is one of many subtypes of Charcot-Marie-Tooth disease (CMT). CMT is a collective name for inherited diseases of the peripheral nervous system.

HNPP causes episodes of numbness, tingling and/or weakness in response to nerve injury from pressure, stretching or repetitive use. Things that cause these symptoms usually would not affect a normal individual. When injured, the nerves demyelinate or lose their protective covering. This demyelination is what causes the episodes of numbness and weakness in the injured area. The numbness and weakness is referred to as a ‘pressure palsy'. In time, the nerves recover, or partially recover and remyelinate. (source: hnpp.org)

The onset of HNPP is usually during adolescence or young adulthood, but it can start at any age, either in early childhood or later in life. While exceptions do occur, the majority of patients with HNPP develop initial symptoms around the first or second decade of their life. 

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