Vitamin C is an important vitamin. However, it is advised to avoid vitamin C in high doses (Vitamin C has been shown to reduce PMP22 expression by suppressing PMP22 transcription (sources: https://bestfoot4wardblog.com/2020/02/20/hnpp-the-latest/ and https://n.neurology.org/content/82/10_Supplement/P7.089 -
Brett Parker, Sezgi Arpag, Raymond Roos, Jun Li Effect of Ascorbic Acid in Human and Mice with Haploinsufficiency of PMP22 (P7.089), Neurology Journals, April 8, 2014, issue 82, https://doi.org/10.1212/WNL.82.10_supplement.P7.089
! You will still need vitamin C!
Following research states that when one has a casein intolerance (protein in cow's milk), that the antibodies in our bodies also attack a protein called MAG (myelin-associated glycoprotein). This protein is either important for the myelin in the central nervous system and for the myelin in the peripheral nervous system. Although this is a recent finding, and this hasn't been tested for HNPP, it might be worth to replace cow's milk for a few weeks in order to find out if this makes a difference. There are a lot of alternatives. Please check with a medical professional if you want to replace cow's milk.
Source: https://www.pnas.org/doi/10.1073/pnas.2117034119 Chunder R, Weier A, Mäurer H, Luber N, Enders M, Luber G, Heider T, Spitzer A, Tacke S, Becker-Gotot J, Kurts C, Iyer R, Ho PP, Robinson WH, Lanz TV, Kuerten S. Antibody cross-reactivity between casein and myelin-associated glycoprotein results in central nervous system demyelination. Proc Natl Acad Sci U S A. 2022 Mar 8;119(10):e2117034119. doi: 10.1073/pnas.2117034119. Epub 2022 Mar 2. PMID: 35235454; PMCID: PMC8916005.
To be avoided in high doses
(source: CMTA USA: https://www.facebook.com/CMTAssociation/posts/did-you-know-megadoses-of-vitamin-b6-pyridoxine-are-potentially-harmful-for-peop/565928290093996/)
in progress
in progress
There are different supplements that support (or claim to support) the nervous system.
Unfortunately, there is no research on supplementation and the results in people with HNPP. Below you will find some supplements that are on the various social media pages or online. I can't stress enough that you always have to consult a medical professional before taking supplements. Every patient is different.